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How can a woman get pregnant with bone marrow

It may be hard to get and stay pregnant for some would-be mums, but there is hope. Scientists have discovered the vital role bone marrow plays in pregnancy, which can lead to new therapies in the future. In 10 seconds? Stem cells play a key role in successful pregnancies. Read the science. What exactly was discovered?

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How bone marrow boosts chances of a healthy pregnancy

Log in Advanced Search. A study in mice suggests that bone marrow-derived stem cells may play a role in establishing pregnancy. The research showed that the stem cells can travel through blood circulation to the uterus, making it more receptive for a new embryo. Specifically, the authors showed that these cells concentrate in the lining of the uterus where the embryo is about to implant.

There, they become specialised uterine cells or decidual cells, which are critical for maintaining the embryo. Previous studies had shown that small numbers of bone-marrow stem cells contribute to the renewal of the lining of the non-pregnant uterus, but it remained unknown whether they play a part in pregnancy.

This study is the first to show a physiological role for bone-marrow stem cells in pregnancy. This work was possible due to a methodological breakthrough. Dr Taylor and his team at Yale were able to develop a mild chemotherapy for their mouse model that 'wiped out' the bone marrow of these mice without affecting their eggs, and therefore their fertility. Then they fertilised these mice before and after healthy bone-marrow transplantation to investigate whether the bone-marrow stem cells contributed to the establishment of pregnancy.

The team also used mice that lack a protein called Hoxa11, usually expressed in both uterine and bone marrow progenitor cells - mice without this protein have a deficient womb and cannot become pregnant. Mice that only partially lack Hoxa11 can become pregnant, but they experience recurrent miscarriages. When these mice received bone marrow transplants from healthy mice, both sets were able to become pregnant.

The partially-deficient mice went ahead to have as many pregnancies as their healthy mice. Several studies have implicated Hoxa11 production and conditions that relate in pregnancy failure, such as endometriosis.

The authors suggest further investigations for the role of Hoxa11 and bone-marrow stem cells in the human pregnancy and its establishment.

By posting a comment you agree to abide by the BioNews terms and conditions. Syndicate this story - click here to enquire about using this story. Home Articles News Comment Reviews. Archive Current edition Subscribe. Donating time Financial support. Objectives Background Reader testimonials People. Writing articles Writing scheme. Log in Register. Healthy bone marrow may be important in fertility 23 September By Dr Nicoletta Charolidi. Appeared in BioNews Stem cells show potential to restore fertility after chemotherapy.

Artificial sperm made from stem cells. Scientists grow sperm from human bone marrow. New eggs from bone marrow stem cells? By posting a comment you agree to abide by the BioNews terms and conditions Syndicate this story - click here to enquire about using this story. Advertise your products and services HERE - click for further details. Website developed and built by Ultimate Database Ltd. Subscribe to the BioNews newsletter for free.

Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy. Bone marrow may be the missing piece of the fertility puzzle. Cells that make bone marrow also travel to the womb to help pregnancy. Woman's bone marrow may determine her fertility.

Forensics find donor DNA in semen of bone marrow transplant patient. Decreased fertility and increased risk of miscarriages in older women is linked to a protein involved in egg cell division, scientists say.

A stem-cell therapy in mice shows promise for reversing infertility in women who have received cancer treatment Scientists in Japan have successfully generated viable sperm cells from embryonic stem cells in mice. The sperm cells were able to fertilise eggs and for the first time this produced healthy, fertile offspring Scientists have claimed success in growing immature sperm cells from bone marrow, which they hope to employ in fertility treatments within five years.

Bone marrow stem cells can produce new eggs in adult mice, US researchers say. A team based at Massachusetts General Hospital has shown that the eggs of mice rendered sterile with a drug can regenerate within 24 hours, and that these germ cells originate from bone marrow. The findings, published

Bone marrow stem cells may be vital for pregnancy

Credit: Getty Images. The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy.

Become a fan of Slashdot on Facebook. I guess after being told to "Go Fuck Yourself" for so many years, these scientists finally found a way to do it. There will be some interesting debates raging about this one for a long time.

Log in Advanced Search. A study in mice suggests that bone marrow-derived stem cells may play a role in establishing pregnancy. The research showed that the stem cells can travel through blood circulation to the uterus, making it more receptive for a new embryo. Specifically, the authors showed that these cells concentrate in the lining of the uterus where the embryo is about to implant.

Bone marrow may be the missing piece of the fertility puzzle

Bone marrow-derived cells play a role in changes to the mouse uterus before and during pregnancy, enabling implantation of the embryo and reducing pregnancy loss, according to research published September 12 in the open-access journal PLOS Biology. Although the study was done in mice, it raises the possibility that dysfunction of bone marrow-derived progenitor cells may contribute to implantation failure and pregnancy loss in women. Bone marrow progenitors can become either blood or tissue cells. Within the uterus they differentiate into endometrial tissue cells in the lining of the womb, but until now it was not known if they have a function in pregnancy. Reshef Tal and colleagues from Yale School of Medicine developed a bone marrow transplantation protocol that preserved ovary and reproductive function, allowing them for the first time to track these cells in pregnancy, showing that during pregnancy cells from the bone marrow were preferentially recruited to the uterus and were concentrated near the site of implantation, on the maternal side of the placenta. The authors demonstrate that after reaching the uterus, these cells proliferate and become so-called decidual cells, specialized uterine cells which are critical for nurturing the embryo and supporting its implantation. The authors then made use of mice that lack Hoxa11, a protein which is found in uterine cells but also in bone marrow-derived progenitor cells; these mice are known to have defects in the womb lining and are unable to become pregnant. Mice with partial Hoxa11 deficiency can become pregnant but have recurrent pregnancy losses. Strikingly, the authors found that after receiving bone marrow transplants from healthy mice, the Hoxadeficient mice switched on genes involved in preparing the womb lining for pregnancy and became pregnant. In mice with partial Hoxa11 deficiency, bone marrow transplant from healthy mice prevented pregnancy loss resulting in normal litter numbers.

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Researchers found that when an egg is fertilised, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy. Study first author Dr. Using mice, researchers found that a bone marrow transplant from a healthy donor could improve fertility.

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Human bone marrow has been used to create early-stage sperm cells for the first time, a scientific step forward that will help researchers understand more about how sperm cells are created. For the experiment, Prof Nayernia and his team took bone marrow from male volunteers and isolated the mesenchymal stem cells. These cells have previously been found to grow into other body tissues such as muscle.

Woman’s bone marrow may determine her fertility

Methods and results: Autologous embryos from in vitro-fertilized ova were successfully implanted in a year-old woman, 2 years after successful allogeneic bone marrow transplant BMT for chronic myeloid leukemia CML. A second pregnancy, similarly initiated, is in progress at 4 years posttransplant. Conclusion: Our experience offers a fertility-salvaging technique to some women after cytotoxic therapy, where time permits ovarian hyperstimulation before the need for definitive myeloblative therapy of their malignancy, and where the risk of subsequent infertility is high. This site needs JavaScript to work properly.

But recently a team of scientists announced they had made artificial sperm from human bone marrow , and media reports abounded with the dire news that my goodfellas and by extension, me had been rendered unnecessary. There are at least half a dozen reasons why such speculation is silly, some scientific and some practical. For example, as long as sex feels good and remains no more expensive than dinner and a bottle of wine, most people will use natural-grown sperm. Still, suggests Gregory Stock, director of the program on medicine, society and technology at the UCLA School of Medicine and the CEO of a biotech company called Signum Biosciences, it is very interesting that there were any stories at all. Experiments have created eggs and sperm, so-called artificial gametes, from embryonic stem cells and other cell types for years now with limited success, so the bone marrow work does not represent a giant leap.

Pregnancy in Bone Marrow Failure Disease

Since the late s, scientists have explored how to produce sperm where all of the chromosomes come from a female donor. Creating female sperm was first raised as a possibility in a patent filed in [3] by injecting a woman's cells into a man's testicles, though the patent focused mostly on injecting altered male cells into a man's testes to correct genetic diseases. In , Japanese scientists partially confirmed such techniques by creating chicken female sperm in a similar manner. It is therefore concluded that most of the W-bearing PGC could not differentiate into spermatozoa because of restricted spermatogenesis. One potential roadblock to injecting a woman's cells into a man's testicles is that the man's immune system might attack and destroy the woman's cells. In usual circumstances, when foreign cells such as cells or organs from other people, or infectious bacteria are put into a human body, its immune system will reject such cells or organs. However, a special property of a man's testicles is that they are immune-privileged , that is, a man's immune system will not attack foreign cells such as a woman's cells injected into the sperm-producing part of the testicles.

Sep 12, - A woman's bone marrow may determine her ability to start and sustain a pregnancy, report Yale researchers in PLOS Biology. The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation.

The breakthrough paves the way for lesbian couples to have children that are biologically their own. Researchers at Newcastle upon Tyne University say their technique will help lead to new treatments for infertility. But critics warn that it sidelines men and raises the prospect of babies being born through entirely artificial means. The research centres around stem cells - the body's 'mother' cells which can turn into any other type of cell.

Female sperm

It may be hard to get and stay pregnant for some would-be mums, but there is hope. Scientists have discovered the vital role bone marrow plays in pregnancy, which can lead to new therapies in the future. In 10 seconds? Stem cells play a key role in successful pregnancies.

How bone marrow boosts chances of a healthy pregnancy

Bone marrow failure diseases frequently occur in women who are young and of child bearing age. People with these diseases have legitimate concerns about whether a pregnancy will cause their infants to suffer from the disease or its treatment, or whether their own disease will relapse. But the goal of modern therapy and modern obstetrics is to minimize both maternal and fetal complications. Experience from published reports suggests that in the past ten years, both maternal health and fetal outcomes have improved in women with aplastic anemia and PNH.

The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation.

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