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Can a woman get pregnant using bone marrow

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The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy. But knowing that bone marrow has a significant role is a paradigm shift. In this study, the researchers were able to prove the physiological relevance of stem cells to pregnancy.

SEE VIDEO BY TOPIC: Stem cells offer a way to study infertility's causes

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SEE VIDEO BY TOPIC: Susie Rabaca: Pregnant Woman with Leukemia Finds Bone Marrow Match - Localish

Stem Cells and Same Sex Reproduction

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Credit: Getty Images. The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy.

But knowing that bone marrow has a significant role is a paradigm shift. In this study, the researchers were able to prove the physiological relevance of stem cells to pregnancy.

In two mouse models with the Hoxa11 gene defect, which presents in mice as a defective endometrium, the researchers found that a bone marrow transplant from a healthy donor could improve fertility by promoting sufficient decidualization of the endometrium. In mice with only one copy of the defective gene, the transplant saved pregnancies that would otherwise have been lost and increased litter sizes, while in the mice with two bad copies of the gene, which were thus entirely infertile, the transplant caused growth and repair of the defective endometria.

This study was possible due to a methods breakthrough that Tal and Taylor made a few years ago. Before a bone marrow transplant , chemotherapy or radiation clears the body of the existing bone marrow, so that the donor bone marrow can take its place. Though more research is needed prior to clinical trials, Tal and Taylor see hope for the patients they treat for infertility on the clinical side of their practice in this latest advance.

Bone marrow can be considered another critical reproductive organ. This finding opens up a new potential avenue for treatment of a condition that has been untreatable in the past. Leet and Clara Guthrie Patterson Fellowship funded the research. Source: Yale University.

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Female sperm

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Since the late s, scientists have explored how to produce sperm where all of the chromosomes come from a female donor. Creating female sperm was first raised as a possibility in a patent filed in [3] by injecting a woman's cells into a man's testicles, though the patent focused mostly on injecting altered male cells into a man's testes to correct genetic diseases. In , Japanese scientists partially confirmed such techniques by creating chicken female sperm in a similar manner.

But recently a team of scientists announced they had made artificial sperm from human bone marrow , and media reports abounded with the dire news that my goodfellas and by extension, me had been rendered unnecessary. There are at least half a dozen reasons why such speculation is silly, some scientific and some practical. For example, as long as sex feels good and remains no more expensive than dinner and a bottle of wine, most people will use natural-grown sperm. Still, suggests Gregory Stock, director of the program on medicine, society and technology at the UCLA School of Medicine and the CEO of a biotech company called Signum Biosciences, it is very interesting that there were any stories at all. Experiments have created eggs and sperm, so-called artificial gametes, from embryonic stem cells and other cell types for years now with limited success, so the bone marrow work does not represent a giant leap.

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Human bone marrow has been used to create early-stage sperm cells for the first time, a scientific step forward that will help researchers understand more about how sperm cells are created. For the experiment, Prof Nayernia and his team took bone marrow from male volunteers and isolated the mesenchymal stem cells. These cells have previously been found to grow into other body tissues such as muscle. They cultured these cells in the laboratory and coaxed them into becoming male reproductive cells, which are scientifically known as 'germ cells'. Genetic markers showed the presence of partly-developed sperm cells called spermatagonial stem cells, which are an early phase of the male germ cell development. In most men, spermatagonial cells eventually develop into mature, functional sperm but this progression was not achieved in this experiment. Earlier research led by Prof Nayernia using mice, published in Laboratory Investigations, also created spermatagonial cells from mouse bone marrow. The cells were transplanted into mouse testes and were observed to undergo early meiosis - cell division - the next stage to them becoming mature sperm cells, although they did not develop further.

Will science render men unnecessary?

Credit: Getty Images. The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy. But knowing that bone marrow has a significant role is a paradigm shift. In this study, the researchers were able to prove the physiological relevance of stem cells to pregnancy.

Stem cells have generated such an enormous amount of interest, in part, because of their applications related to areas such as fertility and genetics. In that same light, their interest for solving reproductive challenges has also generated a great deal of controversy.

Become a fan of Slashdot on Facebook. I guess after being told to "Go Fuck Yourself" for so many years, these scientists finally found a way to do it. There will be some interesting debates raging about this one for a long time.

Bone stem cells turned into primitive sperm cells

By Roxanne Khamsi. In a first step towards creating artificial sperm cells, researchers have turned human bone marrow tissue into primitive sperm cells. If these precursor cells can be coaxed into becoming fully functioning sperm cells, the technique could allow infertile men to father their own children, and even allow women to produce their own sperm.

Methods and results: Autologous embryos from in vitro-fertilized ova were successfully implanted in a year-old woman, 2 years after successful allogeneic bone marrow transplant BMT for chronic myeloid leukemia CML. A second pregnancy, similarly initiated, is in progress at 4 years posttransplant. Conclusion: Our experience offers a fertility-salvaging technique to some women after cytotoxic therapy, where time permits ovarian hyperstimulation before the need for definitive myeloblative therapy of their malignancy, and where the risk of subsequent infertility is high. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Bone marrow may be the missing piece of the fertility puzzle

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May 8, - Same-sex reproduction may eventually be possible through the use of stem cells. In a recent experiment, bone marrow stem cells were extracted from men and Whether or not the eggs can actually produce viable offspring, to have a biological child that belongs both to me and to a woman I love has.

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Bone marrow stem cells may be vital for pregnancy

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Comments: 3
  1. Akinojas

    What entertaining question

  2. Gozahn

    No, opposite.

  3. Faugal

    Seriously!

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